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Harrisburg is a community that is now located within the city of Houston, Texas, United States. The community is located east of downtown Houston, south of the Brays Bayou and Buffalo Bayou junction, and west of Brady's Island. 

Harrisburg/Manchester has a history which predates Houston. Harrisburg was a community located at the confluence of Brays Bayou and Buffalo Bayou before the Texas Revolution. It was burned by Santa Anna's army on their way to defeat at San Jacinto. Houston, established upstream of the devastated community later that year, quickly overtook and eclipsed Harrisburg. By 1927 the area was a part of Houston, dependent on the adjacent Port of Houston.

Harrisburg / Manchester is a neighborhood in Houston, Texas with a population of 3,919. Harrisburg / Manchester is in Harris County. Living in Harrisburg / Manchester offers residents a sparse urban feel and most residents own their homes. In Harrisburg / Manchester there are a lot of parks. Many families live in Harrisburg / Manchester and residents tend to be liberal. The public schools in Harrisburg / Manchester are above average.

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